Short Time One-Spot Synthesis of 2, 4, 5-Trisubstituted- Imidazoles Using Morpholinium Hydrogen Sulphate as Green and Reusable Catalysts

Morpholinium hydrogen Sulphate as Brønsted acidic ionic liquid was used as an efficient and reusable catalyst for the onepot synthesis of 2,4,5-trisubstituted imidazoles that achieved by three component cyclocondensation of 1,2-dicarbonyl compound, aromatic or aliphatic aldehyde and ammonium acetate under thermal solvent-free conditions. The key advantages of this process are cost effectiveness of catalyst, reusability of catalyst, easy work-up and purification of products by non-chromatographic methods, excellent yields and very short time reactions. Multicomponent reactions (MCRs) have drawn great interest enjoying an outstanding status in modern organic synthesis and medicinal chemistry because they are one-pot processes bringing together three or more components and show high atom economy and high selectivity.